InnateDB Protein
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IDBP-164804.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mtap1s
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Protein Name
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microtubule-associated protein 1S
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000019405
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InnateDB Gene
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IDBG-164802 (Mtap1s)
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Protein Structure
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Function |
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles. {ECO:0000250, ECO:0000269PubMed:15528209}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15528209}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:15528209}. Note=Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. Detected in filopodia-like protrusions and synapses (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in ventral and dorsal horns of the spinal cord, hippocampus, cerebral cortex, molecular, Purkinje and granular cell layers of the cerebellum and in dorsal root ganglia of the PNS (at protein level). Expressed in brain, testis, heart, lung, kidney and liver. {ECO:0000269PubMed:15528209, ECO:0000269PubMed:16297881}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443304
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InterPro |
IPR001279
Beta-lactamase-like
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PFAM |
PF00753
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PRINTS |
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PIRSF |
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SMART |
SM00849
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C052
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PhosphoSite |
PhosphoSite-Q8C052
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
270058
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UniGene |
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RefSeq |
NP_766601
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MGI ID |
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MGI Symbol |
Map1s
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OMIM |
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CCDS |
CCDS22387
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HPRD |
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IMGT |
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EMBL |
AC019302
AK032300
AK162124
BC052828
DQ387862
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GenPept |
AAH52828
ABD47683
BAC27800
BAE36739
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