Version 5.4
Mus musculus Protein: Ttll11
Summary
InnateDB Protein IDBP-164845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttll11
Protein Name tubulin tyrosine ligase-like family, member 11
Synonyms 4932702F08Rik; 4933424A20Rik; AU043211; D2Ertd624e;
Species Mus musculus
Ensembl Protein ENSMUSP00000028248
InnateDB Gene IDBG-164843 (Ttll11)
Protein Structure
UniProt Annotation
Function Polyglutamase which preferentially modifies alpha- tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Required for CCSAP localization to both spindle and cilia microtubules. {ECO:0000269PubMed:17499049}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:17499049}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain, kidney, liver, lung, muscle and testis. {ECO:0000269PubMed:17499049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016874 ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0018095 protein polyglutamylation
GO:0051013 microtubule severing
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:1921660
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4Q9F4
PhosphoSite PhosphoSite-
TrEMBL E0CY35
UniProt Splice Variant
Entrez Gene 74410
UniGene Mm.412643
RefSeq NP_084050
MGI ID
MGI Symbol Ttll11
OMIM
CCDS CCDS50579
HPRD
IMGT
EMBL AK016577 AL732413 AL773525 AL845477 AM690755 BC115858
GenPept AAI15859 BAB30318 CAM84332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca