InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asprv1

Summary

InnateDB Protein

IDBP-164886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asprv1

Protein Name

aspartic peptidase, retroviral-like 1

Synonyms

2300003P22Rik; AA986851; SASP; SASPase; Taps;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046121

InnateDB Gene

IDBG-164884 (Asprv1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

Disease Associations

Tissue Specificity

Highly expressed in stratified epithelia in skin, tongue, esophagus, forestomach and vagina. Also expressed in trachea, urinary bladder and thymus. Undetectable in simple epithelia. Within the epidermis, expressed exclusively in the granular layer (at protein level). Levels are elevated in benign skin tumors but are down-regulated in squamous cell carcinomas. {ECO:0000269PubMed:16565508, ECO:0000269PubMed:16837463}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0043588	skin development

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1915105

InterPro

IPR001995 Peptidase A2A, retrovirus, catalytic
IPR018061 Peptidase A2A, retrovirus RVP subgroup
IPR019103 Aspartic peptidase, DDI1-type
IPR021109 Aspartic peptidase domain

PFAM

PF00077
PF09668

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q09PK2

PhosphoSite