InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc6l

Summary

InnateDB Protein

IDBP-164908.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc6l

Protein Name

excision repair cross-complementing rodent repair deficiency complementation group 6 - like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050592

InnateDB Gene

IDBG-164906 (Ercc6l)

Protein Structure

UniProt Annotation

Function

DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (By similarity). {ECO:0000250}.

Subcellular Localization

Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed mainly in the neural tube and heart of E10.5 embryo. Significantly down-regulated after alcohol exposure in embryonic brain and heart, but not in embryonic kidney, liver, or lung. {ECO:0000269PubMed:15917148}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0007067	mitotic nuclear division
GO:0008150	biological_process
GO:0008152	metabolic process

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005575	cellular_component
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2654144

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021006 Histone deacetylase complex, subunit 2/3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF04851
PF00270
PF11496

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BHK9