Version 5.4
Mus musculus Protein: Thg1l
Summary
InnateDB Protein IDBP-164914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thg1l
Protein Name tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000011398
InnateDB Gene IDBG-164912 (Thg1l)
Protein Structure
UniProt Annotation
Function Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008193 tRNA guanylyltransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1913878
InterPro IPR007537 tRNAHis guanylyltransferase Thg1
IPR024956 tRNAHis guanylyltransferase catalytic domain
PFAM PF04446
PRINTS
PIRSF PIRSF028980
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CY52
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66628
UniGene Mm.476927
RefSeq NP_001074438
MGI ID
MGI Symbol Thg1l
OMIM
CCDS CCDS36132
HPRD
IMGT
EMBL AK010876 AL645948 BC092541 BC115560 BC115561
GenPept AAH92541 AAI15561 AAI15562 BAB27240 CAI25024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca