InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: L3mbtl2

Summary

InnateDB Protein

IDBP-164941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

L3mbtl2

Protein Name

l(3)mbt-like 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023029

InnateDB Gene

IDBG-164939 (L3mbtl2)

Protein Structure

UniProt Annotation

Function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14597177}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:14597177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding
GO:0042393	histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process
GO:0016568	chromatin modification