InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrnb2

Summary

InnateDB Protein

IDBP-164983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrnb2

Protein Name

cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)

Synonyms

[b]2-nAchR; Acrb-2; Acrb2; C030030P04Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029562

InnateDB Gene

IDBG-164981 (Chrnb2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001508	action potential
GO:0001661	conditioned taste aversion
GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007271	synaptic transmission, cholinergic
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0014059	regulation of dopamine secretion
GO:0019233	sensory perception of pain
GO:0021562	vestibulocochlear nerve development
GO:0021631	optic nerve morphogenesis
GO:0021771	lateral geniculate nucleus development
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021955	central nervous system neuron axonogenesis
GO:0030890	positive regulation of B cell proliferation
GO:0032225	regulation of synaptic transmission, dopaminergic
GO:0032226	positive regulation of synaptic transmission, dopaminergic
GO:0033603	positive regulation of dopamine secretion
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0035176	social behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042113	B cell activation
GO:0042220	response to cocaine
GO:0042320	regulation of circadian sleep/wake cycle, REM sleep
GO:0042391	regulation of membrane potential
GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045471	response to ethanol
GO:0045759	negative regulation of action potential
GO:0048814	regulation of dendrite morphogenesis
GO:0050877	neurological system process
GO:0050890	cognition
GO:0051291	protein heterooligomerization
GO:0051899	membrane depolarization
GO:0051963	regulation of synapse assembly
GO:0060084	synaptic transmission involved in micturition

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:87891

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERK7