InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam19

Summary

InnateDB Protein

IDBP-165046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam19

Protein Name

a disintegrin and metallopeptidase domain 19 (meltrin beta)

Synonyms

AL024287; Mltnb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000011400

InnateDB Gene

IDBG-165044 (Adam19)

Protein Structure

UniProt Annotation

Function

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed, with the highest expression in bone, heart and lung, followed by brain and spleen and relatively low expression in liver, skeletal muscle, kidney and testis. In bone, primarily expressed in cell of the osteoblast lineage and not detected in mature osteoclasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0007507	heart development

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:105377

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt