Version 5.4
Mus musculus Protein: Phka1
Summary
InnateDB Protein IDBP-165084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phka1
Protein Name phosphorylase kinase alpha 1
Synonyms 5330411D17; 9830108K24Rik; Phka;
Species Mus musculus
Ensembl Protein ENSMUSP00000061991
InnateDB Gene IDBG-165082 (Phka1)
Protein Structure
UniProt Annotation
Function Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations Note=Defects in Phka1 are the cause of phosphorylase kinase deficiency in I-strain mice.
Tissue Specificity Both isoforms are expressed in muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005516 calmodulin binding
Biological Process
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:97576
InterPro IPR008928 Six-hairpin glycosidase-like
IPR011613 Glycoside hydrolase family 15
PFAM PF00723
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18826
PhosphoSite PhosphoSite-P18826
TrEMBL Q8BSV5
UniProt Splice Variant
Entrez Gene 18679
UniGene Mm.212889
RefSeq NP_032858
MGI ID
MGI Symbol Phka1
OMIM
CCDS CCDS30323
HPRD
IMGT
EMBL AK030426 AK163548 AL732405 AL805925 M28867 X73877 X74616
GenPept AAA39927 BAC26957 BAE37392 CAA52085 CAA52687 CAM15410 CAM17599

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca