InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgs1

Summary

InnateDB Protein

IDBP-165200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgs1

Protein Name

prostaglandin-endoperoxide synthase 1

Synonyms

Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059977

InnateDB Gene

IDBG-165198 (Ptgs1)

Protein Structure

UniProt Annotation

Function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Subcellular Localization

Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0004666	prostaglandin-endoperoxide synthase activity
GO:0005515	protein binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006693	prostaglandin metabolic process
GO:0006979	response to oxidative stress
GO:0008217	regulation of blood pressure
GO:0019371	cyclooxygenase pathway
GO:0030216	keratinocyte differentiation
GO:0042127	regulation of cell proliferation
GO:0055114	oxidation-reduction process