Version 5.4
Mus musculus Protein: Cyfip2
Summary
InnateDB Protein IDBP-165312.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyfip2
Protein Name cytoplasmic FMR1 interacting protein 2
Synonyms 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; mKIAA1168; Pir121;
Species Mus musculus
Ensembl Protein ENSMUSP00000090853
InnateDB Gene IDBG-165306 (Cyfip2)
Protein Structure
UniProt Annotation
Function Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. {ECO:0000250UniProtKB:Q96F07, ECO:0000269PubMed:11438699}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11438699}. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes. {ECO:0000269PubMed:11438699}.
Disease Associations
Tissue Specificity Expressed in hippocampus (at protein level). {ECO:0000269PubMed:24153177}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1924134
InterPro IPR008081 Cytoplasmic FMR1-interacting
IPR016536 Cytoplasmic FMR1-interacting, subgroup
PFAM PF05994
PRINTS PR01698
PIRSF PIRSF008153
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SQX6
PhosphoSite PhosphoSite-Q5SQX6
TrEMBL Q8K118
UniProt Splice Variant
Entrez Gene 76884
UniGene Mm.407410
RefSeq NP_001239388
MGI ID
MGI Symbol Cyfip2
OMIM
CCDS CCDS24573
HPRD
IMGT
EMBL AB093288 AF162472 AF334144 AK030397 AK147224 AK147586 AK147632 AL662806 AL713958 BC028941 BC049232
GenPept AAD45803 AAH28941 AAH49232 AAK81821 BAC26942 BAC41472 BAE27779 BAE28010 BAE28036 CAI24844 CAI25371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca