InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NANOG

Summary

InnateDB Protein

IDBP-16536.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NANOG

Protein Name

Nanog homeobox

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000229307

InnateDB Gene

IDBG-16534 (NANOG)

Protein Structure

UniProt Annotation

Function

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269PubMed:15983365, ECO:0000269PubMed:16000880, ECO:0000269PubMed:16391521}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:15983365}.

Disease Associations

Tissue Specificity

Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. {ECO:0000269PubMed:12787504, ECO:0000269PubMed:12787505, ECO:0000269PubMed:14990856, ECO:0000269PubMed:15982323, ECO:0000269PubMed:16391521}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 156 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	156 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001710	mesodermal cell fate commitment
GO:0001714	endodermal cell fate specification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008406	gonad development
GO:0009790	embryo development
GO:0009880	embryonic pattern specification
GO:0010033	response to organic substance
GO:0010454	negative regulation of cell fate commitment
GO:0010468	regulation of gene expression
GO:0017145	stem cell division
GO:0019827	stem cell maintenance
GO:0030154	cell differentiation
GO:0030514	negative regulation of BMP signaling pathway
GO:0032526	response to retinoic acid
GO:0035019	somatic stem cell maintenance
GO:0045595	regulation of cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation