Version 5.4
Mus musculus Protein: Tob2
Summary
InnateDB Protein IDBP-165367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tob2
Protein Name transducer of ERBB2, 2
Synonyms 2900090N22Rik; 4930545K18Rik; AV071822; mKIAA1663;
Species Mus musculus
Ensembl Protein ENSMUSP00000061390
InnateDB Gene IDBG-165365 (Tob2)
Protein Structure
UniProt Annotation
Function Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042809 vitamin D receptor binding
Biological Process
GO:0010468 regulation of gene expression
GO:0045671 negative regulation of osteoclast differentiation
GO:0045778 positive regulation of ossification
Cellular Component
Protein Structure and Domains
PDB ID MGI:1888525
InterPro IPR002087 Anti-proliferative protein
IPR009818 Ataxin-2, C-terminal
PFAM PF07742
PF07145
PRINTS PR00310
PIRSF
SMART SM00099
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JM55
PhosphoSite PhosphoSite-
TrEMBL Q8BP12
UniProt Splice Variant
Entrez Gene 57259
UniGene Mm.431591
RefSeq NP_065253
MGI ID
MGI Symbol Tob2
OMIM
CCDS CCDS27673
HPRD
IMGT
EMBL AB041225 AK044343 AK078476 AK143542 BC011163 BC094031
GenPept AAH11163 AAH94031 BAA94606 BAC31878 BAC37295 BAE25428

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca