InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irx2

Summary

InnateDB Protein

IDBP-165400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irx2

Protein Name

Iroquois related homeobox 2 (Drosophila)

Synonyms

IRX6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073976

InnateDB Gene

IDBG-165398 (Irx2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in specific and overlapping patterns with Irx1 and Irx3 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is found in the loop of Henle in the S3 proximal tubule segment and in the thick ascending limb (TAL) of the distal tubule. {ECO:0000269PubMed:17875669}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001656	metanephros development
GO:0006355	regulation of transcription, DNA-templated
GO:0072086	specification of loop of Henle identity
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development