InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ryr1

Summary

InnateDB Protein

IDBP-165405.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ryr1

Protein Name

ryanodine receptor 1, skeletal muscle

Synonyms

AI528790; Ryr; RYR-1; skrr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032813

InnateDB Gene

IDBG-165403 (Ryr1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006936	muscle contraction
GO:0006937	regulation of muscle contraction
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030314	junctional membrane complex
GO:0030315	T-tubule
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:99659

InterPro

IPR000699 RIH (RyR and IP3R Homology) domain
IPR001870 B30.2/SPRY domain
IPR003032 Ryanodine receptor Ryr
IPR003877 SPla/RYanodine receptor SPRY
IPR003961 Fibronectin, type III
IPR005821 Ion transport domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009460 Ryanodine Receptor TM 4-6
IPR013333 Ryanodine receptor
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif
IPR018355 SPla/RYanodine receptor subgroup

PFAM