InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akap8

Summary

InnateDB Protein

IDBP-165423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akap8

Protein Name

A kinase (PRKA) anchor protein 8

Synonyms

1200016A02Rik; AA673585; AKAP95; AU015639;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002699

InnateDB Gene

IDBG-165421 (Akap8)

Protein Structure

UniProt Annotation

Function

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). {ECO:0000250}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:16751186}. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007076

mitotic chromosome condensation

Cellular Component

GO:0000793	condensed chromosome
GO:0001939	female pronucleus
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016363	nuclear matrix