Version 5.4
Mus musculus Protein: Mreg
Summary
InnateDB Protein IDBP-165507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mreg
Protein Name melanoregulin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041878
InnateDB Gene IDBG-165505 (Mreg)
Protein Structure
UniProt Annotation
Function Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells. {ECO:0000269PubMed:15550542, ECO:0000269PubMed:17260955}.
Subcellular Localization Apical cell membrane {ECO:0000269PubMed:17260955}; Peripheral membrane protein {ECO:0000269PubMed:17260955}. Note=Localizes to the inner segment and basal outer segment of rods in the retina.
Disease Associations
Tissue Specificity Expressed in retinal pigment epithelium (at protein level). Widely expressed with higher expression in skin, heart, liver, testis and thymus. {ECO:0000269PubMed:15550542, ECO:0000269PubMed:17260955}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030318 melanocyte differentiation
GO:0032402 melanosome transport
GO:0042640 anagen
GO:0043473 pigmentation
GO:0048066 developmental pigmentation
Cellular Component
GO:0016324 apical plasma membrane
GO:0042470 melanosome
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2151839
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NVG5
PhosphoSite PhosphoSite-Q6NVG5
TrEMBL
UniProt Splice Variant
Entrez Gene 381269
UniGene Mm.478226
RefSeq NP_001005423
MGI ID
MGI Symbol Mreg
OMIM
CCDS CCDS15032
HPRD
IMGT
EMBL AY628210 BC068125
GenPept AAH68125 AAV32092

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca