InnateDB Protein
|
IDBP-165516.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Babam1
|
Protein Name
|
RIKEN cDNA 5430437P03 gene
|
Synonyms
|
5430437P03Rik; Merit40;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000002473
|
InnateDB Gene
|
IDBG-165514 (Babam1)
|
Protein Structure
|
|
Function |
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double- strand breaks (DSBs). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
54 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1915501
|
InterPro |
IPR002035
von Willebrand factor, type A
|
PFAM |
PF00092
|
PRINTS |
|
PIRSF |
|
SMART |
SM00327
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q3UI43
|
PhosphoSite |
PhosphoSite-Q3UI43
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
68251
|
UniGene |
|
RefSeq |
NP_080912
|
MGI ID |
|
MGI Symbol |
Babam1
|
OMIM |
|
CCDS |
CCDS40381
|
HPRD |
|
IMGT |
|
EMBL |
AK003366
AK077402
AK078265
AK147083
BC005692
|
GenPept |
AAH05692
BAB22740
BAC36785
BAC37197
BAE27663
|
|
|