InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Antxr1

Summary

InnateDB Protein

IDBP-165519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Antxr1

Protein Name

anthrax toxin receptor 1

Synonyms

2310008J16Rik; 2810405N18Rik; Antrx1; Tem8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045634

InnateDB Gene

IDBG-165517 (Antxr1)

Protein Structure

UniProt Annotation

Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=At the membrane of lamellipodia and at the tip of actin- enriched filopodia. Colocalizes with actin at the base of lamellipodia (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

Biological Process

GO:0007165	signal transduction
GO:0022414	reproductive process
GO:0031532	actin cytoskeleton reorganization
GO:0034446	substrate adhesion-dependent cell spreading

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1916788

InterPro

IPR002035 von Willebrand factor, type A
IPR008399 Anthrax toxin receptor, C-terminal
IPR008400 Anthrax toxin receptor, extracellular
IPR017360 Anthrax toxin receptor

PFAM

PF00092
PF05586
PF05587

PRINTS

PIRSF

PIRSF038023

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt