Mus musculus Protein: Polr3h | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-165567.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Polr3h | ||||||||||||
Protein Name | polymerase (RNA) III (DNA directed) polypeptide H | ||||||||||||
Synonyms | 5031409G22Rik; RPC8; | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000023113 | ||||||||||||
InnateDB Gene | IDBG-165563 (Polr3h) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:1926179 | ||||||||||||
InterPro |
IPR004519
DNA-directed RNA polymerase, subunit E/RPC8 IPR005576 RNA polymerase Rpb7, N-terminal IPR012340 Nucleic acid-binding, OB-fold IPR013238 RNA polymerase III, subunit Rpc25 |
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PFAM |
PF03876
PF08292 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q9D2C6 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 78929 | ||||||||||||
UniGene | |||||||||||||
RefSeq | NP_084505 | ||||||||||||
MGI ID | |||||||||||||
MGI Symbol | Polr3h | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS27676 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AK019868 BC010793 | ||||||||||||
GenPept | AAH10793 BAB31893 | ||||||||||||