InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp1

Summary

InnateDB Protein

IDBP-165642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp1

Protein Name

ubiquitin specific peptidase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030289

InnateDB Gene

IDBG-165640 (Usp1)

Protein Structure

UniProt Annotation

Function

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:O94782}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0001501	skeletal system development
GO:0006281	DNA repair
GO:0006282	regulation of DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0009411	response to UV
GO:0016579	protein deubiquitination
GO:0035520	monoubiquitinated protein deubiquitination