InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rin3

Summary

InnateDB Protein

IDBP-165674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rin3

Protein Name

Ras and Rab interactor 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060771

InnateDB Gene

IDBG-165672 (Rin3)

Protein Structure

UniProt Annotation

Function

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity
GO:0017137	Rab GTPase binding

Biological Process

GO:0007165	signal transduction
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0043547	positive regulation of GTPase activity