InnateDB Protein
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IDBP-165755.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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March4
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Protein Name
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membrane-associated ring finger (C3HC4) 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000042803
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InnateDB Gene
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IDBG-165753 (March4)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2683550
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InterPro |
IPR011016
Zinc finger, RING-CH-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF12906
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00744
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TIGRFAMs |
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Modification |
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SwissProt |
Q80TE3
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PhosphoSite |
PhosphoSite-Q80TE3
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TrEMBL |
Q6PHM2
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UniProt Splice Variant |
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Entrez Gene |
381270
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UniGene |
Mm.397653
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RefSeq |
NP_001038998
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MGI ID |
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MGI Symbol |
March4
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OMIM |
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CCDS |
CCDS15034
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HPRD |
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IMGT |
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EMBL |
AK122502
BC056494
BC098191
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GenPept |
AAH56494
AAH98191
BAC65784
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