InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alcam

Summary

InnateDB Protein

IDBP-165767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alcam

Protein Name

activated leukocyte cell adhesion molecule

Synonyms

AI853494; BEN; CD166; DM-GRASP; MuSC; SC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023312

InnateDB Gene

IDBG-165765 (Alcam)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in the brain, and lung, and at lower levels in the liver, and the kidney, as well as by activated leukocytes and a number of cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0008045	motor neuron axon guidance

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome