InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtpbp3

Summary

InnateDB Protein

IDBP-165812.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtpbp3

Protein Name

GTP binding protein 3

Synonyms

2410009F13Rik; AI607903;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092892

InnateDB Gene

IDBG-165806 (Gtpbp3)

Protein Structure

UniProt Annotation

Function

GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:14680828}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in tissues with high metabolic rates including heart, liver and brain. Weakly expressed in skeletal muscle. {ECO:0000269PubMed:14680828}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006400	tRNA modification

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1917609

InterPro

IPR018948 GTP-binding protein TrmE, N-terminal

PFAM

PF10396

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q923K4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

70359

UniGene

Mm.486680

RefSeq

MGI ID

MGI Symbol

Gtpbp3

OMIM

CCDS

HPRD

IMGT

EMBL

AF361482 AY029613 BC092042

GenPept

AAH92042 AAK35216 AAK60410