InnateDB Protein
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IDBP-165873.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Npat
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Protein Name
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nuclear protein in the AT region
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000048709
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InnateDB Gene
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IDBG-165871 (Npat)
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Protein Structure
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Function |
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (By similarity). Required for early embryonic development. {ECO:0000250, ECO:0000269PubMed:9199343}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17003125}. Note=Concentrates in Cajal bodies tethered to histone gene clusters. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
GO:0000083
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regulation of transcription involved in G1/S transition of mitotic cell cycle
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GO:0006351
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transcription, DNA-templated
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GO:0010468
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regulation of gene expression
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:107605
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InterPro |
IPR006594
LisH dimerisation motif
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00667
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BMA5
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PhosphoSite |
PhosphoSite-Q8BMA5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
244879
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UniGene |
Mm.400154
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RefSeq |
NP_001074621
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MGI ID |
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MGI Symbol |
Npat
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OMIM |
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CCDS |
CCDS40637
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HPRD |
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IMGT |
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EMBL |
AC156640
AK033012
AK042624
AK053074
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GenPept |
BAC28125
BAC31308
BAC35255
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