InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ftcd

Summary

InnateDB Protein

IDBP-165900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ftcd

Protein Name

formiminotransferase cyclodeaminase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001183

InnateDB Gene

IDBG-165898 (Ftcd)

Protein Structure

UniProt Annotation

Function

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity). {ECO:0000250}.Binds and promotes bundling of vimentin filaments originating from the Golgi. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=More abundantly located around the mother centriole. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005542	folic acid binding
GO:0016740	transferase activity
GO:0030409	glutamate formimidoyltransferase activity
GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity

Biological Process

GO:0006548	histidine catabolic process
GO:0007010	cytoskeleton organization
GO:0008152	metabolic process
GO:0019556	histidine catabolic process to glutamate and formamide
GO:0019557	histidine catabolic process to glutamate and formate
GO:0035999	tetrahydrofolate interconversion
GO:0044237	cellular metabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005814	centriole
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1339962

InterPro

IPR004227 Formiminotransferase catalytic domain
IPR007044 Cyclodeaminase/cyclohydrolase
IPR012886 Formiminotransferase, N-terminal subdomain
IPR013802 Formiminotransferase, C-terminal subdomain
IPR022384 Formiminotransferas, N- and C-terminal subdomains

PFAM

PF04961
PF07837
PF02971

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91XD4

PhosphoSite