Version 5.4
Mus musculus Protein: Chga
Summary
InnateDB Protein IDBP-165908.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chga
Protein Name chromogranin A
Synonyms ChrA;
Species Mus musculus
Ensembl Protein ENSMUSP00000021610
InnateDB Gene IDBG-165906 (Chga)
Protein Structure
UniProt Annotation
Function Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle {ECO:0000269PubMed:12388744}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:12388744}. Secreted {ECO:0000269PubMed:12388744}. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:88394
InterPro IPR001819 Chromogranin A/B
IPR001990 Chromogranin/secretogranin
PFAM PF01271
PRINTS PR00659
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26339
PhosphoSite PhosphoSite-P26339
TrEMBL Q3UN28
UniProt Splice Variant
Entrez Gene 12652
UniGene Mm.4137
RefSeq NP_031719
MGI ID
MGI Symbol Chga
OMIM
CCDS CCDS26120
HPRD
IMGT
EMBL AK144504 BC026554 M64278
GenPept AAA37457 AAH26554 BAE25920

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca