InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prokr1

Summary

InnateDB Protein

IDBP-165917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prokr1

Protein Name

prokineticin receptor 1

Synonyms

EG-VEGFR1; Gpr73; Pkr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059034

InnateDB Gene

IDBG-165915 (Prokr1)

Protein Structure

UniProt Annotation

Function

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007623	circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0060976	coronary vasculature development

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1929676

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JKL1