InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfkbiz

Summary

InnateDB Protein

IDBP-165945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfkbiz

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

Synonyms

AA408868; INAP; Mail;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041173

InnateDB Gene

IDBG-165943 (Nfkbiz)

Protein Structure

UniProt Annotation

Function

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11086164, ECO:0000269PubMed:11278262, ECO:0000269PubMed:11356851, ECO:0000269PubMed:15618216}.

Disease Associations

Tissue Specificity

Expressed in kidney, liver, lung and heart. Expressed at very low levels in skeletal muscle, spleen and brain. {ECO:0000269PubMed:11356851}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006954	inflammatory response
GO:0045087	innate immune response (InnateDB)