InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itpk1

Summary

InnateDB Protein

IDBP-165956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpk1

Protein Name

inositol 1,3,4-triphosphate 5/6 kinase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046027

InnateDB Gene

IDBG-165954 (Itpk1)

Protein Structure

UniProt Annotation

Function

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016853	isomerase activity
GO:0047325	inositol tetrakisphosphate 1-kinase activity
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity