InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cul5

Summary

InnateDB Protein

IDBP-166025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cul5

Protein Name

cullin 5

Synonyms

4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; VACM-1; VACM1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034529

InnateDB Gene

IDBG-166023 (Cul5)

Protein Structure

UniProt Annotation

Function

Core component of multiple SCF-like ECS (Elongin BC- Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. {ECO:0000269PubMed:23806657}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 335 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	335 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006970	response to osmotic stress
GO:0016567	protein ubiquitination
GO:0051480	cytosolic calcium ion homeostasis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031466	Cul5-RING ubiquitin ligase complex