InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIP4

Summary

InnateDB Protein

IDBP-16605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIP4

Protein Name

thyroid hormone receptor interactor 4

Synonyms

ASC-1; ASC1; HsT17391; ZC2HC5;

Species

Homo sapiens

Ensembl Protein

ENSP00000261884

InnateDB Gene

IDBG-16603 (TRIP4)

Protein Structure

UniProt Annotation

Function

Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20873783}. Cytoplasm {ECO:0000269PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation. Colocalizes with NEK6 in the centrosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0008270	zinc ion binding
GO:0016922	ligand-dependent nuclear receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-templated