Version 5.4
Homo sapiens Protein: ANO9
Summary
InnateDB Protein IDBP-16608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO9
Protein Name anoctamin 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332788
InnateDB Gene IDBG-16606 (ANO9)
Protein Structure
UniProt Annotation
Function Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22946059}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22946059}; Multi-pass membrane protein {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:1902476 chloride transmembrane transport
GO:1902939 negative regulation of intracellular calcium activated chloride channel activity
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1A5B4
PhosphoSite PhosphoSite-A1A5B4
TrEMBL
UniProt Splice Variant
Entrez Gene 338440
UniGene Hs.501622
RefSeq NP_001012302
HUGO HGNC:20679
OMIM
CCDS CCDS31326
HPRD 18214
IMGT
EMBL AC138230 AK074088 AK096874 AK303642 BC128557
GenPept AAI28558 BAB84914 BAG53386 BAG64646

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca