InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc27a1

Summary

InnateDB Protein

IDBP-166082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc27a1

Protein Name

solute carrier family 27 (fatty acid transporter), member 1

Synonyms

Fatp; FATP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034267

InnateDB Gene

IDBG-166080 (Slc27a1)

Protein Structure

UniProt Annotation

Function

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FatP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. {ECO:0000269PubMed:10593920, ECO:0000269PubMed:11970897, ECO:0000269PubMed:12937175, ECO:0000269PubMed:14991074, ECO:0000269PubMed:15699031, ECO:0000269PubMed:15897321, ECO:0000269PubMed:9671728}.

Subcellular Localization

Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm. Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.

Disease Associations

Tissue Specificity

Highest expression in skeletal muscle, heart and fat. Lower levels in brain, kidney, lung and liver. No expression in spleen or intestine. {ECO:0000269PubMed:9671728}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0015245	fatty acid transporter activity
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001579	medium-chain fatty acid transport
GO:0001676	long-chain fatty acid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006659	phosphatidylserine biosynthetic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008152	metabolic process
GO:0009409	response to cold
GO:0015908	fatty acid transport
GO:0015909	long-chain fatty acid transport
GO:0031652	positive regulation of heat generation
GO:0032049	cardiolipin biosynthetic process
GO:0032868	response to insulin
GO:0033211	adiponectin-activated signaling pathway
GO:0071072	negative regulation of phospholipid biosynthetic process
GO:0071902	positive regulation of protein serine/threonine kinase activity