InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a19

Summary

InnateDB Protein

IDBP-166091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a19

Protein Name

solute carrier family 6 (neurotransmitter transporter), member 19

Synonyms

4632401C08Rik; B<0>AT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022048

InnateDB Gene

IDBG-166089 (Slc6a19)

Protein Structure

UniProt Annotation

Function

Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269PubMed:15044460}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expression observed in kidney, small intestine, and skin. Expression not observed in other organs, such as lung, skeletal muscle, brain, liver and pancreas. In kidney, expression is localized in the renal cortex but not in the medulla. Substantial amounts of expression in the proximal tubules. The distal nephron segments and the glomeruli are consistently negative. In the small intestine, expression is exclusively localized in villus enterocytes. High resolution of the hybridization-positive villi reveals a gradient of expression with the highest levels in apical cells. Not detected in crypt cells or in any other cell types of the small intestine. {ECO:0000269PubMed:15044460}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005515	protein binding
GO:0015175	neutral amino acid transmembrane transporter activity

Biological Process

GO:0006836	neurotransmitter transport
GO:0007584	response to nutrient
GO:0015804	neutral amino acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome