InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgcd

Summary

InnateDB Protein

IDBP-166102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgcd

Protein Name

sarcoglycan, delta (dystrophin-associated glycoprotein)

Synonyms

35kDa; delta-SG;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076459

InnateDB Gene

IDBG-166100 (Sgcd)

Protein Structure

UniProt Annotation

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000269PubMed:9864373}; Single-pass type II membrane protein {ECO:0000269PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9864373}.

Disease Associations

Tissue Specificity

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0061024

membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016011	dystroglycan complex
GO:0016012	sarcoglycan complex
GO:0016021	integral component of membrane
GO:0042383	sarcolemma