Version 5.4
| Mus musculus Protein: Btbd7 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-166144.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Btbd7 | ||||||
| Protein Name | BTB (POZ) domain containing 7 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000046951 | ||||||
| InnateDB Gene | IDBG-166142 (Btbd7) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. {ECO:0000269PubMed:20671187}. | ||||||
| Subcellular Localization | Nucleus {ECO:0000269PubMed:11527404}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Specifically expressed in embryonic epithelia. {ECO:0000269PubMed:20671187}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1917858 | ||||||
| InterPro |
IPR000210
BTB/POZ-like IPR011333 BTB/POZ fold IPR011705 BTB/Kelch-associated IPR013069 BTB/POZ |
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| PFAM |
PF07707
PF00651 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00225
SM00875 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q8CFE5 | ||||||
| PhosphoSite | PhosphoSite-Q8CFE5 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 238386 | ||||||
| UniGene | |||||||
| RefSeq | NP_766394 | ||||||
| MGI ID | |||||||
| MGI Symbol | Btbd7 | ||||||
| OMIM | |||||||
| CCDS | CCDS26125 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AK033160 AK122522 BC041669 BC057303 | ||||||
| GenPept | AAH41669 AAH57303 BAC28177 BAC65804 | ||||||