Version 5.4
Mus musculus Protein: Strbp
Summary
InnateDB Protein IDBP-166158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Strbp
Protein Name spermatid perinuclear RNA binding protein
Synonyms 6430510M02Rik; AI852513; C230082I21Rik; C86322; Spnr;
Species Mus musculus
Ensembl Protein ENSMUSP00000072047
InnateDB Gene IDBG-166154 (Strbp)
Protein Structure
UniProt Annotation
Function Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA. {ECO:0000250, ECO:0000269PubMed:11336498, ECO:0000269PubMed:7744952}.
Subcellular Localization Isoform 2: Cytoplasm, cytoskeleton. Note=Microtubule-associated that localizes to the manchette in developing spermatids.
Disease Associations
Tissue Specificity Isoform 2 is expressed in spermatocytes (at protein level). Expressed in testis, thymus, ovary, liver, kidney, heart, spleen and brain. Expressed in cortex, dentate gyrus and Purkinje cell layer and granule cells of the cerebellum. {ECO:0000269PubMed:11336498, ECO:0000269PubMed:7744952}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
Biological Process
GO:0006928 cellular component movement
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
GO:0007638 mechanosensory behavior
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:104626
InterPro IPR006561 DZF
IPR014720 Double-stranded RNA-binding domain
PFAM PF07528
PF00035
PRINTS
PIRSF
SMART SM00572
SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WM1
PhosphoSite PhosphoSite-Q91WM1
TrEMBL Q9CVW0
UniProt Splice Variant
Entrez Gene 20744
UniGene Mm.477856
RefSeq XP_006497880
MGI ID
MGI Symbol Strbp
OMIM
CCDS CCDS38118
HPRD
IMGT
EMBL AK006314 AL805959 AL953890 BC014710 BX545905 X84692
GenPept AAH14710 BAB24521 CAA59167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca