InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jtb

Summary

InnateDB Protein

IDBP-166185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jtb

Protein Name

jumping translocation breakpoint

Synonyms

Gm622;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029546

InnateDB Gene

IDBG-166183 (Jtb)

Protein Structure

UniProt Annotation

Function

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity (By similarity). Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. {ECO:0000250, ECO:0000269PubMed:17369841}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269PubMed:17369841}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019901	protein kinase binding

Biological Process

GO:0000910	cytokinesis
GO:0007067	mitotic nuclear division
GO:0008637	apoptotic mitochondrial changes
GO:0042127	regulation of cell proliferation
GO:0045860	positive regulation of protein kinase activity