Version 5.4
Mus musculus Protein: Sln
Summary
InnateDB Protein IDBP-166251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sln
Protein Name sarcolipin
Synonyms 2310045A07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000036950
InnateDB Gene IDBG-166249 (Sln)
Protein Structure
UniProt Annotation
Function Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis. {ECO:0000269PubMed:21697544, ECO:0000269PubMed:22961106}.
Subcellular Localization Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in heart atrium, red gastrocnemius muscle and soleus. Detected at lower levels in the extensor digitorum longus muscle (at protein level). {ECO:0000269PubMed:21697544}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030234 enzyme regulator activity
Biological Process
GO:0051924 regulation of calcium ion transport
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:1901077 regulation of relaxation of muscle
GO:1901894 regulation of calcium-transporting ATPase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1913652
InterPro IPR008028 Sarcolipin
PFAM PF05366
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQD6
PhosphoSite PhosphoSite-Q9CQD6
TrEMBL
UniProt Splice Variant
Entrez Gene 66402
UniGene
RefSeq NP_079816
MGI ID
MGI Symbol Sln
OMIM
CCDS CCDS40640
HPRD
IMGT
EMBL AK008863 AK008896 AK009005 AK009809 BC028496
GenPept AAH28496 BAB25959 BAB26019 BAB26516

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca