InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc12a7

Summary

InnateDB Protein

IDBP-166265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc12a7

Protein Name

solute carrier family 12, member 7

Synonyms

AA408796; D13Ertd261e; Kcc4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017900

InnateDB Gene

IDBG-166261 (Slc12a7)

Protein Structure

UniProt Annotation

Function

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. {ECO:0000250, ECO:0000269PubMed:11976689}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23376777}; Multi-pass membrane protein {ECO:0000269PubMed:23376777}.

Disease Associations

Note=Defects in Slc12a7 are a cause of deafness due to the progressive degeneration of outer and inner hair cells in the cochlea and of neurons in the cochlear ganglion, leading to the loss of the organ of Corti. {ECO:0000269PubMed:11976689}.

Tissue Specificity

Detected in proximal tubules in the kidney, in particular in basolateral membranes of intercalated cells in the cortical collecting duct.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006884	cell volume homeostasis
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport