Version 5.4
Mus musculus Protein: Atg4c
Summary
InnateDB Protein IDBP-166315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg4c
Protein Name autophagy-related 4C (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000030279
InnateDB Gene IDBG-166313 (Atg4c)
Protein Structure
UniProt Annotation
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C- terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation. {ECO:0000250, ECO:0000269PubMed:17442669}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0015031 protein transport
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2651854
InterPro IPR005078 Peptidase C54
PFAM PF03416
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q811C2
PhosphoSite PhosphoSite-Q811C2
TrEMBL
UniProt Splice Variant
Entrez Gene 242557
UniGene Mm.241663
RefSeq NP_778194
MGI ID
MGI Symbol Atg4c
OMIM
CCDS CCDS18382
HPRD
IMGT
EMBL AJ312233 AL627166 BC058981
GenPept AAH58981 CAC85555 CAM26343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca