InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OR1D2

Summary

InnateDB Protein

IDBP-16632.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OR1D2

Protein Name

olfactory receptor, family 1, subfamily D, member 2

Synonyms

OLFR1; OR17-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000327585

InnateDB Gene

IDBG-16630 (OR1D2)

Protein Structure

UniProt Annotation

Function

Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception. {ECO:0000269PubMed:12663925, ECO:0000269PubMed:15458659, ECO:0000269PubMed:16820410}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16820410}; Multi-pass membrane protein {ECO:0000269PubMed:16820410}. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

Disease Associations

Tissue Specificity

Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium. {ECO:0000269PubMed:12663925, ECO:0000269PubMed:15458659, ECO:0000269PubMed:16820410}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004984	olfactory receptor activity

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007338	single fertilization
GO:0007608	sensory perception of smell
GO:0050911	detection of chemical stimulus involved in sensory perception of smell

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000725 Olfactory receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00245

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34982