InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmd8

Summary

InnateDB Protein

IDBP-166324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmd8

Protein Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

Synonyms

6720456J22Rik; AA407360; AL033291; AL033322; AL033323; C76433;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051657

InnateDB Gene

IDBG-166322 (Psmd8)

Protein Structure

UniProt Annotation

Function

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005838	proteasome regulatory particle
GO:0022624	proteasome accessory complex
GO:0070062	extracellular vesicular exosome