InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crtc2

Summary

InnateDB Protein

IDBP-166336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crtc2

Protein Name

CREB regulated transcription coactivator 2

Synonyms

4632407F12Rik; mTORC2; Torc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029545

InnateDB Gene

IDBG-166334 (Crtc2)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008140	cAMP response element binding protein binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0032793	positive regulation of CREB transcription factor activity
GO:0042593	glucose homeostasis
GO:0043970	histone H3-K9 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051289	protein homotetramerization