InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Magee1

Summary

InnateDB Protein

IDBP-166385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Magee1

Protein Name

melanoma antigen, family E, 1

Synonyms

AI847422; DAMAGE; mMage-e1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094078

InnateDB Gene

IDBG-166383 (Magee1)

Protein Structure

UniProt Annotation

Function

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:14623885}. Nucleus {ECO:0000269PubMed:14623885}. Cell membrane {ECO:0000269PubMed:14623885}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane.

Disease Associations

Tissue Specificity

Expressed in cell bodies and dendrites of hippocampal and Purkinje neurons. Also expressed in peripheral nerve, where it localizes to the perineurium and myelin (at protein level). Predominantly expressed in brain and at low levels in the heart, liver, kidney, spleen, testis, lung, thymus, placenta and skeletal muscle. {ECO:0000269PubMed:14623885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0030425	dendrite
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm