InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf13c

Summary

InnateDB Protein

IDBP-166391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf13c

Protein Name

tumor necrosis factor receptor superfamily, member 13c

Synonyms

2010006P15Rik; BAFF-R; Baffr; Bcmd; Bcmd-1; Bcmd1; Lvis22;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086564

InnateDB Gene

IDBG-166389 (Tnfrsf13c)

Protein Structure

UniProt Annotation

Function

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269PubMed:11747827}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Note=Defects in Tnfrsf13c are a cause of severe B-cell deficiency. B-cell deficient strain A/WySnJ has a 4.7 kb insertion in the BAFFR gene leading to an altered C-terminus. The mutant RNA is not detectable. B-cell lymphopoiesis is normal, but the life span of peripheral B-cells is much reduced. {ECO:0000269PubMed:11591325}.

Tissue Specificity

Highly expressed in spleen and testis; detected at lower levels in lung and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001782	B cell homeostasis
GO:0002636	positive regulation of germinal center formation
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0031296	B cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0050776	regulation of immune response