Version 5.4
Homo sapiens Protein: PTDSS2
Summary
InnateDB Protein IDBP-16647.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTDSS2
Protein Name phosphatidylserine synthase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308258
InnateDB Gene IDBG-16643 (PTDSS2)
Protein Structure
UniProt Annotation
Function Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006659 phosphatidylserine biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004277 Phosphatidyl serine synthase
PFAM PF03034
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BVG9
PhosphoSite PhosphoSite-Q9BVG9
TrEMBL E9PS47
UniProt Splice Variant
Entrez Gene 81490
UniGene Hs.611221
RefSeq NP_110410
HUGO HGNC:15463
OMIM 612793
CCDS CCDS7696
HPRD 17927
IMGT
EMBL AC137894 AC138230 AL834357 BC001210 CH471158
GenPept AAH01210 CAD39022 EAX02327 EAX02328 EAX02329

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca