InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIP11

Summary

InnateDB Protein

IDBP-16650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIP11

Protein Name

thyroid hormone receptor interactor 11

Synonyms

ACG1A; CEV14; GMAP-210; TRIP-11; TRIP230;

Species

Homo sapiens

Ensembl Protein

ENSP00000267622

InnateDB Gene

IDBG-16648 (TRIP11)

Protein Structure

UniProt Annotation

Function

Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. {ECO:0000269PubMed:10189370, ECO:0000269PubMed:9256431}.

Subcellular Localization

Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:10189370}; Peripheral membrane protein {ECO:0000269PubMed:10189370}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10189370}. Note=Associates with the ends of centrosome-nucleated microtubules.

Disease Associations

Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. {ECO:0000269PubMed:20089971}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. {ECO:0000269PubMed:10189370, ECO:0000269PubMed:9373237}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0003281	ventricular septum development
GO:0006366	transcription from RNA polymerase II promoter
GO:0006412	translation
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0002079	inner acrosomal membrane
GO:0002080	acrosomal membrane
GO:0002081	outer acrosomal membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005840	ribosome
GO:0005856	cytoskeleton
GO:0016020	membrane